Determinants of Bluetongue Virus Virulence in Murine Models of Disease
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چکیده
منابع مشابه
Multiple Genome Segments Determine Virulence of Bluetongue Virus Serotype 8
UNLABELLED Bluetongue virus (BTV) causes bluetongue, a major hemorrhagic disease of ruminants. In order to investigate the molecular determinants of BTV virulence, we used a BTV8 strain minimally passaged in tissue culture (termed BTV8L in this study) and a derivative strain passaged extensively in tissue culture (BTV8H) in in vitro and in vivo studies. BTV8L was pathogenic in both IFNAR(-/-) m...
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15 صفحه اولInvestigation of a bluetongue disease epizootic caused by bluetongue virus serotype 17 in sheep in Wyoming.
OBJECTIVE To characterize a 2007 bluetongue disease (BT) epizootic caused by bluetongue virus (BTV) serotype 17 in sheep in the Big Horn Basin of Wyoming. DESIGN Cross-sectional study. ANIMALS 1,359 sheep from ranches in Wyoming and Montana. PROCEDURES Information on clinical signs and history of BT in sheep was obtained from ranchers and attending veterinarians. At 3 to 6 months after th...
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UNLABELLED Bluetongue virus (BTV) is the causative agent of bluetongue, a major infectious disease of ruminants with serious consequences to both animal health and the economy. The clinical outcome of BTV infection is highly variable and dependent on a variety of factors related to both the virus and the host. In this study, we show that the BTV nonstructural protein NS4 favors viral replicatio...
متن کاملBluetongue virus genetic and phenotypic diversity : towards identifying 1 the molecular determinants that influence virulence and transmission
Bluetongue virus genetic and phenotypic diversity: towards identifying 1 the molecular determinants that influence virulence and transmission 2 potential 3 4 Peter Coetzee, Moritz Van Vuuren , Maria Stokstad, Mette Myrmel, Estelle. H. Venter 5 6 Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of 7 Pretoria, Private Bag X04, Onderstepoort, Pretoria, 0110, So...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2011
ISSN: 0022-538X
DOI: 10.1128/jvi.05226-11